醫學遺傳學及基因體學每月研討會 ─ How Proteomics Makes Us Rethink Our Genome and Transcriptome and Helps Fight Cancers
黃泰中 主治醫師 (臺大醫院內科部)
The Central Dogma of biology is constantly being annotated. Biologists live by it to design their research. Clinicians follow it to develop treatments. New discoveries, however, keep refining it. The list of powerful toolkits for biomedical discovery will not be complete without a burgeoning discipline, proteomics, which is the starter of my talk. Last year, the monumental endeavor to draft the first map of human proteome has uncovered misconstrued parts of human genome including pseudogenes, non-coding RNAs and open reading frames. In the past decade, the advent of new labeling methods and high resolution mass spectrometers has not only widened the application of quantitative proteomics but also made seminal discoveries that were infeasible otherwise. For example, the throughput to measure thousands of proteins helps interrogate how human transcriptome regulates itself, which hence affects protein synthesis globally. At the forefront of disease treatment development, proteomics is also spearheading the revelation of disease mechanism and identification of new therapeutic targets. In this talk, I would love to share with everybody how proteomics helps reshape our understanding about the flow of genetic information. As a physician scientist, I also will detail how proteomics provides an excellent opportunity for us to develop next generation cancer therapy.